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  • The Role Of Pyruvic Acid
    Nov 08, 2018

    Role in metabolism

    Pyruvic acid is a weakly acidic organic acid. It has two functional groups, carbonyl and carboxyl. It has the properties of carboxylic acid and ketone, and has the properties of α-keto acid. It is the simplest α-ketone. Acid (belongs to carbonyl acid). Pyruvic acid is a tricotonic acid produced in the body. It is the final product of the glycolytic pathway. It is reduced to lactic acid in the cytoplasm, or oxidized into mitochondria to form acetyl CoA, enters the tricarboxylic acid cycle, and is oxidized to carbon dioxide. And water, complete the aerobic oxidation energy supply process of glucose. Pyruvate can also convert the sugar, fat and amino acids in the body through the acetyl CoA and the tricarboxylic acid cycle. Therefore, pyruvic acid plays an important pivotal role in the metabolic linkage of the three major nutrients.

    Anti-oxidize effect

    Studies have shown that pyruvate can inhibit the oxidation of oxygen free radicals in rats, and as a hydrogen peroxide scavenger, it has the effect of preventing free radical damage. It has been proven to protect against cardiac reperfusion injury and acute renal failure. The body is resistant to functional damage. Pyruvic acid can play an antioxidant role through two mechanisms: First, as an α-keto acid, pyruvic acid can directly inhibit hydrogen peroxide by non-enzymatic decarbonation reaction; second, supplementation with pyruvic acid can enhance The citric acid cycle, after increased citrate production, inhibits phosphofructokinase, thereby entering the pentose phosphate bypass, producing reduced coenzyme II (NADPH), thereby indirectly increasing the ability of the glutathione (GSH) antioxidant system. Pyruvate also increases the ratio of coenzyme I/reduced coenzyme I (NAD+/NADH) to promote the tricarboxylic acid cycle reaction.