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  • Composition Analysis Of Pharmaceutical Intermediates
    Nov 08, 2018

    Pharmaceutical intermediates can also be called organic intermediates, which are the intermediate products of pesticides, auxiliaries, medicines, dyes, resins, plasticizers, etc., using petroleum or coal tar products as raw materials. It is also called a dye intermediate because it was originally used to make dyes.


    Pharmaceutical intermediates are chemical products or chemical raw materials used in the synthesis of pharmaceuticals. This chemical product, which does not require a production license for a drug, can be produced in an ordinary chemical plant, and can be used for the synthesis of a drug as long as it reaches a certain level. Pharmaceutical intermediates are fine chemical products, and the production of pharmaceutical intermediates has become a major industry in the international chemical industry. The middle includes various classifications of chemical reagents, such as ammonium benzopyrone, oxazolidine and the like. At the same time, as a semi-finished product, pharmaceutical intermediates are fine chemical products, and the production of pharmaceutical intermediates has become a major industry in the international chemical industry. The very large part of the intermediate belongs to the semi-finished product, which belongs to the middle of the process and must be processed by a certain process, that is, it is also an industrial material, not the final product.


    Common pharmaceutical intermediates are: enalkynol; 2-ethylbenzofuran; 3,5-dibromo-4-hydroxybenzoic acid; mitoxantrone; n-chlorophthalimide; 4-methyl- 3-nitroanisole; 6-fluoro-3-piperidin-4-yl-1,2-benzisazole hydrochloride; pregabalin, etc. From the production point of view, most domestic enterprises still At the initial stage, there is still a certain gap compared with pharmaceutical companies such as Europe and the United States. At the same time, the profit margin of producing pharmaceutical intermediates is lower than that of raw materials, and their production processes are similar. Therefore, many companies have already used their own advantages while producing intermediates, while producing raw materials.


    If the production process of pharmaceutical intermediates is improved, the control of production costs is realized, and a suitable method is found to produce the drug substance, a greater profit will be obtained. The analysis of pharmaceutical intermediate products generally uses ion chromatography, infrared spectroscopy (FTIR), mass spectrometry (ms), x-ray diffraction analysis (xrd), nuclear magnetic resonance (1h nmr), icp-ms, and x-ray fluorescence spectroscopy. Through these test methods, the formula of pharmaceutical intermediates can be well analyzed, and the role of the components in the pharmaceutical intermediates can be well understood, and it is more convenient for each enterprise to carry out research and development and grasp the market dynamics.